Following last month’s discussion on microneedling and treatments that align with naturopathic principles, I want to introduce you to one of my favorite regenerative therapies: PRF (Platelet-Rich Fibrin).

If you’ve heard of PRP, you’re already familiar with the concept—and PRF is the next step forward. In fact, PRF is often referred to as the “second generation” of autologous therapies, meaning it is created entirely from your own body and used to support your body’s natural healing processes.

Why This Treatment Matters to Me

Learning about PRP was actually what inspired me to expand into aesthetics. The idea that we could draw a small amount of blood, process it, and use it to stimulate healing, regeneration, and confidence, using nothing but your own blood product, was compelling to me.

Over the past seven years, I’ve continued to evolve this work, and PRF has become a cornerstone of my practice as of recent.

PRF vs PRP: What’s the Difference?

While PRP and PRF are similar, there are a few key differences that make PRF unique:

  • PRP is processed with an anticoagulant to prevent clotting

  • PRF is processed in a plain tube, allowing a natural fibrin matrix to form

This fibrin matrix is what sets PRF apart.

Instead of delivering a quick burst of growth factors (like PRP), PRF releases growth factors slowly over about 10–12 days, creating a more sustained and natural regenerative response.

What’s Inside PRF?

After your blood is drawn and spun in a centrifuge, we isolate the PRF layer and use it for treatment.

This concentrated serum contains:

  • Platelets

  • White blood cells (leukocytes)

  • Cytokines

  • Adhesive proteins

  • Growth factors

The inclusion of white blood cells is especially important—they continue to signal healing and regeneration over time.

PRF works by mimicking your body’s natural wound healing process, increasing growth factors at the treatment site and supporting tissue repair (1).

How PRF Works

While the exact mechanism is still being studied, current research suggests PRF may:

  • Stimulate tissue repair

  • Promote cellular regeneration

  • Enhance collagen production

  • Support new blood vessel formation

  • Influence gene expression related to healing (2)

In simple terms, PRF helps your skin behave like it’s younger—by activating your body’s own repair systems.

How I Use PRF in My Practice

PRF is incredibly versatile and can be used in several ways:

With Microneedling

  • Enhances collagen production

  • Improves results for acne scars and texture

  • Speeds healing and reduces downtime

Under-Eye Rejuvenation

  • Softens hollowing

  • Improves dark circles

  • Enhances skin quality without synthetic filler

Targeted Volume & Skin Support

  • Nasolabial folds

  • Fine lines

  • Areas of early volume loss

Hair Restoration

  • Supports hair growth

  • Improves density and thickness

Why Patients Love PRF

  • 100% natural (from your own body)

  • No synthetic fillers

  • Minimal downtime

  • Gradual, regenerative results

  • Improves skin quality, not just volume

PRF is a tool used in aesthetics that does more than fill or freeze, but rather takes advantage of your body’s innate ability to regenerate and heal itself. It’s one of the most aligned treatments with naturopathic medicine, and one I’m passionate about offering.

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Botox in NE Portland with Dr. Heather Friedman ND: What You Need to Know

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Microneedling Near Me: A Naturopathic Approach to Skin Regeneration